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Related Experiment Video

Updated: Jun 24, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

A Membrane Modification Technique for Left Atrial Appendage Occlusion: A Multicenter Randomized Controlled Trial.

Youqi Fan¹, Dongxing Ma², Changqian Wang³

¹Department of Cardiology of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

|March 6, 2025

Summary

The LAMax occluder, using the SMART technique, proved noninferior to the Watchman device for stroke risk reduction in nonvalvular atrial fibrillation patients. This novel method showed potential in preventing device-related thrombus.

Keywords:

anticoagulant atrial fibrillation device-related thrombus left atrial appendage stroke

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Published on: February 8, 2022

Area of Science:

Cardiology
Medical Devices
Interventional Therapy

Background:

The SMART technique utilizes a negatively ionized polyethylene terephthalate membrane with the LAMax occluder.
This method aims to decrease platelet adhesion and enhance endothelialization.

Purpose of the Study:

To compare the safety and efficacy of the LAMax occluder against the Watchman 2.5 device.
To evaluate stroke risk reduction in patients with nonvalvular atrial fibrillation.

Main Methods:

A total of 236 patients with nonvalvular atrial fibrillation were randomized (1:1) in an open-label study.
Effectiveness endpoints included 12-month successful left atrial appendage sealing and clinical success.
Safety endpoints were assessed, with a noninferiority margin of -7% set for the devices.

Main Results:

The LAMax device demonstrated noninferiority to the Watchman device for LAA sealing (93.2% vs. 89.8%) and clinical success (93.2% vs. 89.8%).
Both devices showed similar 12-month safety endpoints.
No device-related thrombus was observed with the LAMax device, unlike the Watchman device (3-month: 5.7%, 12-month: 4.6%).

Conclusions:

Transcatheter LAAO with the SMART technique and LAMax occluder is a safe and effective stroke prevention strategy for nonvalvular atrial fibrillation.
The novel SMART technique shows promise in preventing device-related thrombus formation.
Further large-scale studies are warranted to confirm these findings for interventional therapies.