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Updated: May 23, 2025
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review
Lauren Frenzel Schuch1, Fábio Muradás Girardi2,3, Laura Borges Kirschnick4
1Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo, Uruguay.
Targeted therapy shows limited efficacy for oral potentially malignant disorders (OPMDs). Further clinical trials are needed to determine if these precision treatments can improve histological outcomes or reduce disease progression.
Area of Science:
- Oncology
- Oral Medicine
- Pharmacology
Background:
- Oral potentially malignant disorders (OPMDs) represent a significant risk for oral cancer development.
- Current management strategies for OPMDs require further optimization.
- Targeted therapies offer a potential avenue for novel OPMD treatment approaches.
Purpose of the Study:
- To systematically review and analyze existing literature on the impact of targeted therapy in managing OPMDs.
- To elucidate the efficacy and safety of various targeted agents used in OPMD treatment.
Main Methods:
- A comprehensive systematic review adhering to PRISMA 2020 guidelines.
- Electronic searches across five databases with no date restrictions, updated in January 2024.
- Inclusion of clinical trials focusing on precision-based targeted therapies for OPMDs.
Main Results:
- Six US-based clinical trials (12-150 participants) were identified.
- Agents like celecoxib, erlotinib, cetuximab, metformin, and nivolumab were evaluated.
- No statistically significant improvements in histology or size were observed; some patients experienced progression and treatment-related toxicity.
Conclusions:
- Current evidence does not support the routine use of targeted therapy for OPMD management.
- Additional well-designed clinical trials are essential to ascertain the true potential of targeted therapies in OPMDs.
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