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Updated: May 23, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Computational fluid dynamics method for determining the rotational diffusion coefficient of cells
Hui Ma1, Steven T Wereley2, Jacqueline C Linnes1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.
Abstract:
This work presents a straightforward computational method to estimate rotational diffusion coefficient of cells and particles of various size using continuum fluid mechanics theory. We calculate the torque ( ) for cells and particles immersed in fluids to find the mobility coefficient and then obtain by substituting in the Einstein relation. Geometries are constructed using triangular mesh, and the model is solved with computational fluid dynamics techniques. This method is less intensive and more efficient than widely used models. We simulate eight different particle geometries and compare the results with previous literature.
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