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Updated: May 23, 2025

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer
Published on: August 20, 2012
AIE and UIA-featured fluorescent ligands for G-quadruplex: the impact of linker rigidity between recognition moiety
1Nation-Regional Engineering Lab for Synthetic Biology of Medicine, International Cancer Center, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, China. humhao1229@szu.edu.cn.
Abstract:
In this study, we designed and synthesized two compounds specifically for the detection of G-quadruplex (G4), a kind of biologically relevant noncanonical nucleic acid structure. One of them, NQ-1, with a rigid linker, showed aggregation-induced emission (AIE) properties, while the other one, NQ-2, with a flexible linker, exhibited unfolding-intramolecular-aggregation-induced emission (UIA) characteristics. Our study demonstrated how adjusting linker rigidity can develop AIE and UIA-based fluorescent probes for G4.
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