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Effect of 0.025% atropine on ocular biometry changes during accommodation
Rohan P J Hughes1, Emily C Woodman-Pieterse1, Scott A Read1
1Centre for Vision and Eye Research, Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Queensland, Australia.
Summary
Low concentration atropine (0.025%) reduces accommodation response and alters ocular biometry during accommodation. This 1-week treatment in myopic participants showed significant changes in eye dimensions, impacting myopia progression insights.
Area of Science:
- Ophthalmology
- Optometry
- Biomedical Engineering
Background:
- Low-concentration atropine is recognized for slowing myopia progression and axial elongation.
- Accommodation, the eye's ability to focus on near objects, influences ocular dimensions.
- Understanding accommodation-induced biometric changes is crucial for myopia management.
Purpose of the Study:
- To quantify the impact of 0.025% atropine eye drops on accommodation-induced ocular biometric changes.
- To assess how atropine affects on-axis ocular dimensions during accommodative effort.
Main Methods:
- Twenty-eight myopic participants (ages 8-25) underwent ocular biometry using an optical biometer and wavefront aberrometry.
- Measurements were taken at 0, 2, 4, and 6 D of accommodation before and after 1 week of nightly 0.025% atropine instillation.
Main Results:
- Accommodation significantly altered anterior chamber depth, vitreous chamber depth, lens thickness, anterior segment length, lens center position, and accommodation response.
- One week of 0.025% atropine reduced accommodation-induced changes in anterior chamber depth and lens thickness.
- Atropine use led to increased anterior chamber depth, anterior segment length, and lens center position, while decreasing vitreous chamber depth, axial length, and accommodation response.
Conclusions:
- One week of 0.025% atropine use effectively reduced the accommodation response and associated on-axis ocular biometric shifts.
- These findings suggest a potential mechanism for atropine's efficacy in myopia control, possibly by modulating the eye's response to near work.
