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Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users.
Yeliz Bulut1,2, Niels Brandt-Jacobsen1,3, Rasmus Madsen1,2
1Department of Nephrology and Endocrinology, Copenhagen University Hospital-Rigshospitalet, Copenhagen DK-2100, Denmark.
The Journal of Clinical Endocrinology and Metabolism
|March 7, 2025
Summary
Previous illicit androgen users show reduced Leydig cell function years after stopping use, impacting erectile function. This study assessed pituitary-testis axis recovery in former anabolic steroid users.
Area of Science:
- Endocrinology
- Reproductive Health
- Sports Medicine
Background:
- Limited understanding of long-term pituitary-testis axis recovery after illicit androgen use.
- Previous studies focused on recent cessation, leaving long-term effects unclear.
Purpose of the Study:
- To evaluate pituitary-testis axis function in men years after discontinuing illicit androgens.
- To compare hormonal function and sexual health between previous users and nonusers.
Main Methods:
- Cross-sectional study of 56 men (30 previous users, 26 nonusers).
- Previous users categorized by detectable or undetectable drug metabolites.
- Hormone stimulation tests (GnRH, hCG) and sexual function questionnaires (IIEF-15) were employed.
Main Results:
- Previous users had significantly lower testosterone secretion post-hCG stimulation compared to nonusers.
- No significant differences in luteinizing hormone (LH) secretion were observed.
- Increased testosterone secretion during hCG testing correlated with better erectile function.
Conclusions:
- Illicit androgen use impairs Leydig cell function for at least two years post-cessation.
- Reduced Leydig cell capacity may contribute to long-term sexual dysfunction, particularly erectile issues.
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