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Updated: May 23, 2025
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Causal associations between Sarcopenia-related traits and obstructive sleep apnea: a mendelian randomization study
Huixian Sun1, Xin Zeng1, Wei Gao2
1Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, No.109 Longmian Avenue, Nanjing, Jiangsu, 211166, China.
Aging Clinical and Experimental Research
|March 7, 2025
Summary
This study found that sarcopenia-related traits like low hand grip strength and muscle mass causally increase the risk of obstructive sleep apnea (OSA). Addressing these factors may help prevent or manage OSA.
Area of Science:
- Gerontology
- Sleep Medicine
- Genetics
Background:
- Limited evidence exists on the causal link between sarcopenia and obstructive sleep apnea (OSA).
- This study investigates the potential causal association between sarcopenia-related traits and OSA.
Purpose of the Study:
- To examine the causal relationship between sarcopenia-related traits and the risk of obstructive sleep apnea (OSA).
- To utilize Mendelian randomization (MR) analyses to assess this association.
Main Methods:
- Employed Mendelian randomization (MR) analyses using genetic instruments for sarcopenia-related traits (hand grip strength, muscle mass, fat mass, water mass, physical performance).
- Utilized large-scale genome-wide association studies (GWAS) data and various MR methods (IVW, MR-Egger, weighted median).
- Assessed pleiotropy and heterogeneity using MR-PRESSO and sensitivity analyses.
Main Results:
- Low hand grip strength (in individuals aged 60+) showed a positive correlation with OSA risk (OR=1.190, p=0.047).
- Muscle mass, fat mass, and water mass were significantly associated with OSA risk.
- Higher body fat percentages and poorer physical performance (e.g., increased fall risk) were linked to increased OSA risk.
Conclusions:
- This MR analysis provides evidence for a causal relationship between sarcopenia characteristics and OSA risk.
- Findings highlight the importance of considering sarcopenia-related factors in OSA management and prevention.
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