Related Experiment Video
Updated: May 23, 2025
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
A Novel 4-Tier Classification for Tumor Budding and the Importance of Tumor Invasive Patterns in the Prognosis of
Tejus V NagiReddy1, Samir Gupta1, Rupali Bavikar2
1Dept. of Surgical Oncology, Dr. D. Y. Patil Medical College, Hospital & Research Center, Pune, India.
Background:
Colorectal carcinoma (CRC) is a major global health issue, with significant morbidity and mortality. Although the TNM staging system remains the standard for prognosticating CRC, it fails to capture the full complexity of tumor behavior. Tumor budding (TB) and tumor invasive patterns (TIPs) are emerging as promising histopathological markers that may provide additional prognostic insights, particularly in predicting the nodal metastasis (N), lymphovascular invasion (LVI), and perineural invasion (PNI). This study aims to assess the correlation between TB, TIP, and CRC prognosis.
Materials And Methods:
This ambidirectional observational study, conducted at our tertiary care center, included 60 biopsy-proven CRC patients, the majority of whom were at stages 2 and 3. Histopathological evaluation of TB and TIP were performed on Hematoxylin and Eosin (H&E) stained slides. TB and TIP categories are then compared against various histopathological parameters. Statistical analysis was performed.
Results:
In the 60 CRC cases studied, low TB was observed in 60% of cases, whereas high TB was seen in 5%. TIP analysis showed that 57% of cases had expansile patterns and 35% of cases had infiltrative patterns. A significant association was found between TB and N (p - 0.018) as well as TIP and PNI (p - 0.016). Multivariate analysis revealed that TB remained a strong predictor for N (OR (odds ratio) = 12.8 and p < 0.001). Although not statistically significant, distinct trends were observed between low and zero TB. Our study's findings on TB and TIP align with several historical studies, reinforcing their prognostic significance in CRC. Despite being a small cohort, our study aligns with these findings, emphasizing TB and TIP as critical prognostic markers in CRC.
Conclusion:
TB and TIP are valuable prognostic tools in CRC, offering insights into tumor behavior and metastasis potential. Their incorporation into routine histopathological evaluation could enhance prognostic accuracy.
More Related Videos
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
10:33Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:30Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...