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Related Experiment Video

Updated: Jun 16, 2025

Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing
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Evolution of organoid genetics.

Thomas M Klompstra1, Ki-Jun Yoon2, Bon-Kyoung Koo3

  • 1Center for Genome Engineering, Institute for Basic Sciences (IBS), Republic of Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea.

European Journal of Cell Biology
|March 8, 2025
PubMed
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This summary is machine-generated.

Organoid technology advances in vitro research, enabling precise modeling of human tissues and diseases. Genetic engineering and emerging tools enhance accuracy for personalized medicine and translational research.

Area of Science:

  • Biotechnology
  • Developmental Biology
  • Stem Cell Research

Background:

  • Organoids offer advanced 3D, multicellular in vitro models of human tissues.
  • Derived from pluripotent stem cells (PSCs) and adult stem cells (AdSCs), they model diverse organs.
  • Organoids significantly advance developmental biology, disease modeling, and drug screening.

Purpose of the Study:

  • To review the evolution of organoid technologies.
  • To highlight the integration of genetic engineering tools in organoid research.
  • To discuss emerging technologies and their impact on future research.

Main Methods:

  • Review of organoid development and applications.
  • Emphasis on genetic tools like CRISPR-Cas9 and prime editing.
Keywords:
CRISPR-Cas9Genetic EngineeringIPSCOrganoidOrganoid GeneticsReview

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  • Inclusion of emerging techniques such as organoid fusion and xenografting.

    • Main Results:

    • Organoids accurately model human-specific pathologies and drug responses.
    • Genetic engineering enables precise manipulation and study of organoid systems.
    • Emerging technologies promise deeper insights into cellular interactions and microenvironments.

    Conclusions:

    • Organoid technology is rapidly evolving, enhancing in vitro research capabilities.
    • Integration of genetic tools and novel methods improves disease modeling and therapeutic screening.
    • Organoids are crucial for personalized medicine and bridging in vitro-in vivo research gaps.