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Updated: May 23, 2025

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
Published on: May 22, 2021
Multifaceted regulation of asymmetric cell division by the actin cytoskeleton
Peishan Yi1, Guangshuo Ou2, Wei Li3
1Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Abstract:
Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement in Caenorhabditis elegans embryos and preprophase band assembly in plants provide valuable insights but fail to fully explain asymmetry establishment in others. In this article, we discuss how actin-dependent mechanisms govern ACD in model systems, highlighting emerging commonalities and differences. Given its broad impact, the actin cytoskeleton may play a more significant role in ACD than currently recognized, serving as a fundamental component during organismal development across kingdoms.
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