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Selective Serotonin Reuptake Inhibitors May Increase Implant Failure.

Michael S Block1, Don Mercante2

  • 1Clinical Professor, Department of Oral and Maxillofacial Surgery, LSU School of Dentistry, Private Practice, Metairie, LA.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|March 8, 2025
PubMed
Summary
This summary is machine-generated.

Patients taking selective serotonin reuptake inhibitors (SSRI) during dental implant surgery showed a significantly higher risk of implant failure within one year. This highlights a potential complication for patients on SSRI medication undergoing dental implant procedures.

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Area of Science:

  • Dental Implantology
  • Pharmacology
  • Clinical Research

Background:

  • Selective serotonin reuptake inhibitors (SSRI) are commonly prescribed medications.
  • Potential association between SSRI use and dental implant failure exists.

Purpose of the Study:

  • To determine the association between SSRI exposure and dental implant failure.
  • Quantify the risk of implant failure in patients using SSRIs.

Main Methods:

  • Retrospective cohort study design.
  • Included patients who received dental implants between December 2007 and February 2020.
  • Analyzed SSRI exposure at implant placement as the predictor variable.

Main Results:

  • SSRI exposure was associated with a 2.8-fold increased risk of implant failure at 1 year (Relative Risk = 2.8; 95% CI, 1.8-4.4).
  • Implant failure rates were 18.6% for SSRI users versus 6.7% for non-users.
  • Comorbidities like smoking, diabetes, osteoporosis, and frailty were also associated with implant failure.

Conclusions:

  • SSRI use at the time of dental implant surgery may increase the risk of implant failure.
  • Clinicians should consider SSRI use when assessing implant failure risk.