Related Experiment Video
Updated: May 23, 2025
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Association between Vitamin D and mortality risk in gout patients
Xinyu Fang1,2, Jie Zhang2,3, Zixing Zhang1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China.
Background:
The correlation between gout patients' 25-hydroxyvitamin D [25(OH)D] levels and their risk of all-cause mortality (ACM) and cardiovascular mortality (CVM) remains inconclusive.
Methods:
Data from 7337 gout patients enrolled in the UK Biobank were analyzed, with death data acquired via connection to national death registries. At baseline, serum 25(OH)D levels were measured. We utilized Cox proportional hazards regression to evaluate the correlations between serum 25(OH)D levels and mortality, and mendelian randomization (MR) analyses to explore causality.
Results:
During 80 176 person-years of following up (median 11.4 years), 659 all-cause deaths were recorded, including 206 cardiovascular disease-related deaths. We found an L-shaped non-linear inverse connection (P non-linearity<0.05) between serum 25(OH)D levels and ACM and CVM with a cutoff value of 45 nmol/L. In contrast to gout patients with <45 nmol/L, those with 25(OH)D levels ≥45 nmol/L had a significantly decreased likelihood of ACM [Hazard Ratio (HR) 0.72; 95% confidence interval 0.61-0.86]. Nonlinear MR also confirmed the causal connection between sufficient 25(OH)D level threshold (≥50 nmol/L) and a reduced likelihood of ACM. Additionally, raising 25(OH)D over the deficiency thresholds (25 nmol/L) could also potentially mitigate CVM (P trend = 0.02).
Conclusions:
Elevated serum 25(OH)D levels are associated with a reduced likelihood of death in gout patients.
More Related Videos
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Related Concept Videos
01:23Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:22Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
01:21Skeleton and Calcium Homeostasis
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:21Cancer Survival Analysis