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Updated: Jun 21, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Subcutaneous undifferentiated pleomorphic sarcoma is more aggressive than pleomorphic dermal sarcoma: Prognosis from
Mathias Ørholt1, Ida Wulff1, Kiya Abebe1
1Copenhagen University Hospital, Department of Plastic Surgery and Burns Treatment, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Introduction:
Subcutaneous undifferentiated pleomorphic sarcoma (scUPS) has not previously been described separately from pleomorphic dermal sarcoma (PDS), and consequently the prognosis for patients with scUPS is unknown.
Materials And Methods:
In this nationwide cohort study, we identified all patients in Denmark diagnosed with scUPS or PDS between 2002 and 2022. The outcomes were 5-year local recurrence, loco-regional and distant metastasis, and overall survival.
Results:
We included 271 patients, 131 with scUPS and 140 with PDS. Patients with scUPS exhibited higher 5-year risks than patients with PDS in terms of the overall risk of metastasis (19 % vs. 7 %, p = 0.006) and distant metastasis only (12 % vs. 2 %, p = 0.004). The 5-year overall survival for patients with scUPS was 50 %, compared to 67 % for patients with PDS (p = 0.004).
Conclusion:
Our findings indicate that patients with scUPS have a significantly worse prognosis than patients with PDS, with a higher overall risk of metastasis and a prolonged metastatic risk. This suggests a more extended follow-up program focusing on the detection of distant metastasis for patients with scUPS, whereas the follow-up of patients with PDS can be limited to clinical controls.
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