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Updated: May 23, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism.

Ayush Kumar1, Kensei Kishimoto1, Hira Lal Goel1

  • 1Departments of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester MA.

Biorxiv : the Preprint Server for Biology
|March 10, 2025
PubMed
Summary

Radiation resistance in triple-negative breast cancer cells enhances metastasis, particularly to bone. This occurs via increased integrin β3 expression, driven by RNA metabolism changes involving HNRNPL and circRNAs.

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