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Preventing peritendinous adhesions using lubricious supramolecular hydrogels
Biorxiv : the Preprint Server for Biology
|March 10, 2025
Summary
New hydrogels prevent scar tissue formation after hand tendon injuries, improving range of motion. These dynamic, bioresorbable barriers offer a promising solution for patients needing quick recovery and unhindered tendon glide.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Peritendinous adhesions are a common complication of flexor tendon injuries, leading to limited range of motion and reduced quality of life.
- Current treatments lack effective solutions for preventing adhesions in the delicate digital space while allowing rapid patient mobilization.
- There is a critical need for advanced materials that can prevent adhesion formation without impeding healing or tendon function.
Purpose of the Study:
- To develop and evaluate dynamically crosslinked, bioresorbable supramolecular hydrogels for preventing peritendinous adhesions.
- To assess the hydrogels' properties, including stability, injectability, and viscoelasticity for facile application.
- To investigate the hydrogels' efficacy and safety in maintaining tendon glide and improving functional recovery post-injury.
Main Methods:
- Development of dynamically crosslinked, bioresorbable supramolecular hydrogels.
- Evaluation of hydrogel-tissue interactions (human tendon and skin) under shear and extensional stress.
- Ex vivo studies on human cadaveric hands with flexor tendon repair.
- Preclinical in vivo studies using a rat Achilles tendon injury model.
Main Results:
- Hydrogels demonstrated a mechanism of adhesion prevention by maintaining a lubricious barrier between tissues.
- Ex vivo studies showed no impairment of tendon gliding or mechanical properties after flexor tendon repair.
- In vivo studies revealed prolonged retention, improved range of motion, and enhanced dorsiflexion recovery.
- Hydrogels proved safe, not compromising tendon strength or healing compared to the standard of care.
Conclusions:
- Dynamically crosslinked, bioresorbable hydrogels effectively prevent peritendinous adhesions.
- These hydrogels offer a novel, easy-to-apply solution with significant translational potential for tendon injury recovery.
- The developed hydrogels maintain tendon function and promote improved functional outcomes post-injury.
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