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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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TNF-α, An Inflammatory Path, Rerouted Through Alternate Medicinal Channels
Shyam Sundar Shanker1, Krishna Santosh Kumar2, Sharmila Hussain3
1Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India.
Journal of Pharmacy & Bioallied Sciences
|March 10, 2025
Summary
Triphala effectively reduces inflammation by targeting the hydrogen sulfide (H2S) pathway. This Ayurvedic medicine demonstrates therapeutic potential in managing inflammatory conditions, particularly in the presence of titanium.
Area of Science:
- Biomedical Science
- Ayurvedic Medicine
- Inflammation Research
Background:
- Inflammatory conditions pose significant health challenges.
- Hydrogen sulfide (H2S) plays a crucial role in mediating inflammatory pathways.
- Titanium (Ti) materials are common in medical implants, potentially interacting with biological processes.
Purpose of the Study:
- To investigate the therapeutic efficacy of triphala on H2S-mediated inflammation.
- To explore the anti-inflammatory mechanisms of triphala in the context of H2S and Ti discs.
Main Methods:
- Treatment of macrophages with triphala extracts.
- Assessment of inflammatory mediators and reactive oxygen species (ROS) production.
- Analysis of TNF mRNA expression and the role of H2S pathway inhibition using propargylglycine.
Main Results:
- Triphala extracts reduced inflammatory mediators and ROS in lipopolysaccharide-treated macrophages.
- Downregulation of TNF mRNA was observed with triphala treatment.
- Triphala's anti-inflammatory effect was linked to the H2S pathway, as evidenced by studies involving propargylglycine.
Conclusions:
- Triphala exhibits significant anti-inflammatory properties.
- The therapeutic action of triphala may involve modulation of the H2S signaling pathway.
- Triphala presents a promising natural therapeutic agent for inflammatory conditions, potentially relevant in biomedical applications involving titanium.
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