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Related Experiment Video

Updated: May 23, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Eggshell Derived Nanohydroxyapatite as a Bone Graft for Intrabony Defects was Evaluated Using (CBCT) - A Randomized

Vishnuvarthan Ganapathy1, Anitha Balaji1, T S Sampath Kumar1

  • 1Department of Periodontics and Implantology, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences
|March 10, 2025
PubMed
Summary

Eggshell-derived nanohydroxyapatite (EnHA) shows promise for bone grafting in intrabony defects. Clinical and CBCT evaluations over six months indicate EnHA

Keywords:
2-wall defect3-wall defectCBCTeggshell-derived hydroxyapatiteintrabony defectlocalized periodontitis

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Area of Science:

  • Biomaterials Science
  • Periodontology
  • Regenerative Medicine

Background:

  • Intrabony defects pose challenges in periodontal regeneration.
  • Novel bone graft materials are needed to improve treatment outcomes.

Purpose of the Study:

  • To evaluate the efficacy of eggshell-derived nanohydroxyapatite (EnHA) as a bone graft material.
  • To assess EnHA's effectiveness in treating intrabony defects using clinical and cone-beam computed tomography (CBCT) parameters.

Main Methods:

  • A 6-month study involving ten patients with intrabony defects, divided into 2-wall and 3-wall defect groups.
  • Clinical assessments included clinical attachment level (CAL), probing depth (PD), and gingival recession (GR).
  • CBCT scans were performed pre-operatively and at multiple follow-up intervals (1, 3, and 5 months).

Main Results:

  • Both groups showed significant reductions in CAL and PD.
  • CBCT measurements indicated positive trends in bone regeneration.
  • The 3-wall defect group demonstrated notable improvements in periodontal health.

Conclusions:

  • EnHA shows potential as a bone graft substitute for intrabony defects.
  • Favorable clinical and CBCT outcomes support EnHA's efficacy over a 6-month period.