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Related Experiment Video

Updated: May 23, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Associations Between Stroke Type, Ischemic Stroke Subtypes, and Poststroke Cognitive Trajectories.

Deborah A Levine^1,2, Rachael T Whitney¹, Wen Ye³

¹Departments of Internal Medicine (D.A.L., R.T.W., J.B.S., A.S.K., R.A.H.), University of Michigan, Ann Arbor.

|March 10, 2025

Summary

Poststroke cognitive decline occurred in multiple domains for stroke survivors. Cognitive trajectories did not significantly differ between ischemic and hemorrhagic stroke types or among ischemic stroke subtypes.

Keywords:

blood pressure cholesterol cognition glucose stroke

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Published on: December 16, 2022

Area of Science:

Neurology
Cognitive Science
Epidemiology

Background:

Poststroke cognitive trajectories vary significantly, but differences by stroke type and subtype remain unclear.
Understanding these differences is crucial for predicting long-term outcomes and developing targeted interventions.

Purpose of the Study:

To investigate the associations between stroke types (ischemic and hemorrhagic) and ischemic stroke subtypes and poststroke cognitive decline.
To analyze changes in global cognition, executive function, and memory following different stroke types and subtypes.

Main Methods:

Pooled data from 4 US cohort studies (1971-2019) including 1143 dementia-free individuals with acute stroke.
Utilized linear mixed-effects models to estimate changes in cognitive function over a median follow-up of 6.0 years.
Standardized cognitive outcomes (global cognition, executive function, memory) as T scores for comparative analysis.

Main Results:

Ischemic stroke survivors exhibited significant declines in global cognition, executive function, and memory.
No significant differences in poststroke cognitive decline were observed between hemorrhagic and ischemic stroke survivors.
Cognitive declines did not differ between small vessel ischemic stroke survivors and survivors of other ischemic stroke subtypes.

Conclusions:

Stroke survivors experience cognitive decline across multiple domains.
Cognitive trajectories following stroke do not appear to differ based on stroke type or specific ischemic stroke subtype.