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Updated: May 23, 2025
Apparatus for Harvesting Tissue Microcolumns
Published on: October 25, 2018
Carboxytherapy in Dermatologic Surgery and Aesthetic Medicine: Current Knowledge and Future Perspectives-A Systematic
Pietro Susini1, Davide di Seclì1, Stefano Bacchini1
1Plastic Surgery Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Background And Objective:
Carboxytherapy (CXT) is a minimally invasive procedure based on percutaneous or subcutaneous microinjections of carbon dioxide. Due to the Bohr effect, it influences the hemoglobin dissociation curve, improving tissue oxygenation, angiogenesis, facilitating vascular perfusion, and lymphatic drainage. Recent evidence suggests unconventional applications in dermatologic surgery and aesthetic medicine; these are focused with the present review.
Methods:
A systematic review was conducted by searching the PubMed library from January 2018 to July 2023, using the terms "Dermatologic Surgery, Aging, Rejuvenation, Scars, Cellulite, Alopecia, AND Carboxy therapy." Eligibility criteria included original studies aimed at discussing CXT in dermatologic surgery and aesthetic medicine.
Results:
The final synthesis included 41 articles distinguished by topic into studies on the role of CXT in facial rejuvenation ( n .14), in cellulite, scars and fat deposits treatment ( n .17), and other pathologic conditions ( n .10). Overall, CXT is an effective antiaging treatment. Furthermore, CXT may play a role in several pathologic conditions including alopecia, lichen planopilaris, vitiligo, chronic diabetic wounds, temporomandibular arthralgia, and lipedema.
Conclusion:
CXT, by promoting tissue oxygenation and microvascular and vascular perfusion, appears to have promising indications for several aesthetic and pathologic conditions, potentially offering satisfactory results with a minimally invasive, safe, and well-tolerated treatment.
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