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Multimodal Pain Control in Headaches Associated With Subarachnoid Hemorrhage.
Lindsey F East1, Leslie A Hamilton, Thomas Christianson2
1Department of Pharmacy, University of Tennessee Medical Center, Knoxville, TN.
Clinical Neuropharmacology
|March 10, 2025
Summary
A new multimodal pain regimen for aneurysmal subarachnoid hemorrhage (aSAH) headaches did not reduce opioid use. While more morphine milligram equivalents were used, pain scores remained unchanged, indicating no significant benefit.
Area of Science:
- Neuroscience
- Pain Management
- Critical Care Medicine
Background:
- Intractable headaches are common in aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Multimodal pain management is standard for acute and chronic pain.
- Evaluating novel pain regimens is crucial for improving patient outcomes.
Purpose of the Study:
- To assess a new multimodal pain regimen for headaches in aSAH patients.
- To compare opioid utilization and pain scores before and after regimen implementation.
- To determine the efficacy of the multimodal approach in reducing pain and opioid consumption.
Main Methods:
- Retrospective study comparing 104 aSAH patients (pre- and post-multimodal regimen).
- Primary endpoint: morphine milligram equivalent (MME) usage in the first 5 days.
- Secondary endpoint: pain scores during the first 5 days of admission.
Main Results:
- Patients receiving the multimodal regimen (n=65) used significantly more MME (82.5) than those without (n=39, 30.0) (P=0.0053).
- No significant difference was observed in median average pain scores between the groups.
- The multimodal pathway did not decrease overall opioid consumption.
Conclusions:
- The implemented multimodal pain pathway for aSAH-associated headaches did not reduce total morphine equivalent utilization.
- Further research is needed to optimize pain management strategies for aSAH patients.
- Current multimodal approaches may require refinement to effectively manage pain and opioid use.
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