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Cell-based immunotherapy in oesophageal cancer
Masoud Lahouty1, Amirhossein Soleymanzadeh2, Sama Kazemi2
1Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of Drug Targeting
|March 10, 2025
Summary
Cell therapy offers new hope for oesophageal cancer (EC) patients, showing promise beyond traditional treatments. This approach, including stem cell and non-stem cell options, is being explored for improved survival and safety in oesophageal squamous cell carcinoma (ESCC).
Area of Science:
- Oncology
- Regenerative Medicine
- Cancer Therapeutics
Background:
- Oesophageal cancer (EC) has a poor prognosis, with high rates of recurrence and metastasis despite conventional treatments like surgery, radiotherapy, and chemotherapy.
- There is a critical need for innovative and effective therapeutic strategies to improve outcomes for EC patients, particularly those with oesophageal squamous cell carcinoma (ESCC).
Purpose of the Study:
- To review the theoretical underpinnings and recent progress in cell therapy for oesophageal cancer.
- To examine current clinical trials and summarize survival and safety data for cell-based treatments in EC.
Main Methods:
- Review of existing literature on cell therapy approaches for oesophageal cancer.
- Analysis of data from ongoing and completed clinical studies involving cell-based treatments.
- Assessment of survival rates and safety profiles reported in relevant studies.
Main Results:
- Cell therapy, encompassing both stem cell and non-stem cell interventions, is emerging as a promising innovative treatment for EC.
- Preliminary data from clinical studies suggest potential benefits in survival and acceptable safety profiles for cell-based therapies in ESCC patients.
Conclusions:
- Cell therapy represents a significant advancement in the treatment landscape for oesophageal cancer, offering a novel therapeutic avenue.
- Further clinical investigation is warranted to fully establish the efficacy and long-term safety of cell-based treatments for EC and ESCC.
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