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Updated: May 23, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
Published on: December 6, 2024
[Technical foundations of large language models]
1Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich, Universität Zürich, Rämistrasse 100, 8091, Zürich, Schweiz. christian.bluethgen@usz.ch.
Background:
Large language models (LLMs) such as ChatGPT have rapidly revolutionized the way computers can analyze human language and the way we can interact with computers.
Objective:
To give an overview of the emergence and basic principles of computational language models.
Methods:
Narrative literature-based analysis of the history of the emergence of language models, the technical foundations, the training process and the limitations of LLMs.
Results:
Nowadays, LLMs are mostly based on transformer models that can capture context through their attention mechanism. Through a multistage training process with comprehensive pretraining, supervised fine-tuning and alignment with human preferences, LLMs have developed a general understanding of language. This enables them to flexibly analyze texts and produce outputs of high linguistic quality.
Conclusion:
Their technical foundations and training process make large language models versatile general-purpose tools for text processing, with numerous applications in radiology. The main limitation is the tendency to postulate incorrect but plausible-sounding information with high confidence.
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