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FK506-binding proteins: Emerging target and therapeutic opportunity in multiple tumors

Hang Ke1, Zihan Chen2, Long Chen1

  • 1Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

International Journal of Biological Macromolecules
|March 10, 2025
PubMed

Insights

FK506-binding proteins (FKBPs) show dual roles in cancer, either promoting or inhibiting tumor growth. Their expression levels can predict patient outcomes, highlighting their potential as cancer biomarkers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • FK506-binding proteins (FKBPs) are implicated in various cancers.
  • They regulate critical signaling pathways like AKT, NF-κB, and p53.
  • These pathways influence cell proliferation, migration, and cell death.

Purpose of the Study:

  • To review the dual roles of FKBP family members in tumorigenesis.
  • To explore the association between FKBP expression and patient prognosis.
  • To identify FKBPs as potential diagnostic and prognostic biomarkers.

Main Methods:

  • Literature review and data synthesis on FKBP family members in cancer.
  • Analysis of FKBP expression levels in relation to tumor types.
  • Correlation analysis between FKBP expression and patient survival data.

Main Results:

  • FKBP family members exhibit context-dependent functions, acting as either oncogenes or tumor suppressors.
  • Altered FKBP expression levels are significantly associated with patient prognosis across different cancers.
  • FKBPs regulate key cancer-related signaling pathways.

Conclusions:

  • FKBP family members play complex roles in cancer development and progression.
  • FKBP expression levels serve as valuable prognostic biomarkers for cancer patients.
  • Future research should integrate single-cell sequencing and clinical validation for precision therapy development.
Keywords:
FK506 binding proteinImmuneTumor microenvironment

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