Recent Advances in Modeling Tissues Using 3D Bioprinted Nanocellulose Bioinks.

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Nanotechnology

Background:

• 3D bioprinting offers superior physiological relevance compared to 2D cultures or animal models.
• Bioinks, such as GelMA and alginate, are crucial for creating 3D tissue constructs.
• Nanocellulose, a material with a collagen-like structure, is emerging as a key component in advanced bioinks.

Purpose of the Study:

• To review recent advancements in nanocellulose-based bioinks for 3D bioprinting.
• To explore the application of nanocellulose in creating specific tissue models.
• To identify future research directions in nanocellulose biofabrication.

Main Methods:

• Review of current literature on nanocellulose applications in bioprinting.
• Analysis of nanocellulose properties relevant to hydrogel formation and tissue mimicry.
• Synthesis of findings on nanocellulose-based models for bone, cartilage, skin, and muscle.

Main Results:

• Nanocellulose forms biocompatible hydrogels with excellent physical properties.
• Its structure mimics collagen, making it suitable for high-collagen tissues.
• Successful application in creating 3D models for bone, cartilage, skin, and muscle has been demonstrated.

Conclusions:

• Nanocellulose is a versatile and promising material for advanced bioinks.
• It enhances the biomimicry and functionality of 3D bioprinted tissue models.
• Further research is needed to optimize nanocellulose for broader tissue engineering applications.