A one-pot multicomponent tandem reaction for the rapid synthesis of 2-amino-3-benzylindoles
Pengyan Zhang1, Chenrui Liu1, Maoyi Dai1
1Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China. taoyuanliang@gxu.edu.cn.
Abstract:
The simultaneous introduction of two functional groups into molecules via a one-pot process is of great importance for the synthesis of complex molecules. However, this remains a challenging task due to the need for precise control of regio- and chemo-selectivity. In this paper, we present a novel oxidative cross-dehydrogenation coupling (CDC) reaction that selectively introduces two nucleophiles at the C2,3-positions of indoles, thereby constructing the C-N and C-C bonds simultaneously in one pot. This method offers a streamlined and efficient approach for functionalizing indoles with high selectivity, expanding the synthetic toolbox for the construction of complex organic frameworks.
More Related Videos
07:36Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Related Concept Videos
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Cycloaddition Reactions: Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
