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Updated: May 23, 2025
Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
Published on: April 3, 2021
Acute Slice Patch-Clamp Recordings to Characterize Neural Populations in the Hippocampal Subgranular Zone
Raquel Bajo-Grañeras1,2,3,4, Alberto Samuel Suárez-Pinilla5,6,7, Magdalena Torres5,6,7
1Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain. rbajo01@ucm.es.
Abstract:
Whole-cell patch clamp allows the evaluation of neuronal excitability and characterization of synaptic transmission. With this technique, it is possible to characterize the neuron maturation level and its integration into the hippocampal circuit. This facilitates the identification of the different stages of neural progenitor cells in the adult brain and their contribution to hippocampal function.
