Related Experiment Video
Updated: May 23, 2025
10:25
Dual-color Correlative Light and Electron Microscopy for the Visualization of Interactions between Mitochondria and Lysosomes
Published on: September 27, 2024
520
Cellular homeostatic responses to lysosomal damage
Jingyue Jia1, Suttinee Poolsup1, Jay E Salinas1
1Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA; Autophagy, Inflammation, and Metabolism Center of Biochemical Research Excellence, Albuquerque, NM 87106, USA.
Trends in Cell Biology
|March 11, 2025
Summary
Cells possess mechanisms to repair damaged lysosomes, crucial for maintaining cellular balance. This review details lysosome repair, remodeling, and its role in disease and therapy.
Area of Science:
- Cell Biology
- Organelle Biology
- Homeostasis
Background:
- Lysosomes are vital organelles regulating cellular homeostasis.
- Lysosomal membranes are susceptible to damage from various stressors.
- Cellular responses to lysosomal damage are critical for survival.
Purpose of the Study:
- To review cellular mechanisms responding to lysosomal damage.
- To highlight processes restoring lysosomal integrity and homeostasis.
- To focus on remodeling, metabolic signaling, and stress granules.
Main Methods:
- Literature review of cellular responses to lysosomal damage.
- In-depth analysis of lysosome remodeling processes.
- Discussion of disease implications and therapeutic strategies.
Main Results:
- Cells activate multiple pathways to address lysosomal damage.
- Key responses include recognition, repair, removal, replacement, and remodeling.
- Metabolic signaling and stress granule formation are central to remodeling.
Conclusions:
- Understanding lysosome repair mechanisms is crucial for cellular health.
- Lysosomal damage contributes to human diseases.
- Targeting lysosomal repair offers therapeutic potential for related disorders.
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