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Updated: Aug 6, 2026
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Imaging Cell Membrane Injury and Subcellular Processes Involved in Repair
Published on: March 24, 2014
Global cellular responses to lysosomal damage
1Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA; Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, Albuquerque, NM 87106, USA.
Current Biology : CB
|July 20, 2026
Summary
Cells have sophisticated ways to respond to lysosome damage, initiating global adaptations in translation, metabolism, and transcription to restore cellular balance and influence health and disease outcomes.
Area of Science:
- Cell Biology
- Molecular Biology
- Organelle Biology
Background:
- Lysosomes are vital organelles involved in cellular processes like degradation, metabolism, and signaling.
- Lysosomal membrane integrity is crucial, as damage contributes to diseases such as neurodegeneration, cancer, and aging.
- Understanding cellular responses to lysosomal damage is critical for addressing various human conditions.
Purpose of the Study:
- To review recent advances in global cellular responses to lysosomal damage.
- To summarize translational, metabolic, and transcriptional adaptations following lysosomal injury.
- To highlight the role of these responses in maintaining cellular homeostasis and disease outcomes.
Main Methods:
- This review synthesizes findings from recent scientific literature.
- It focuses on conceptual advances in understanding cellular damage response mechanisms.
- The review integrates knowledge on local and global cellular adaptations.
Main Results:
- Cells employ local mechanisms to repair, remove, or replace damaged lysosomes.
- Local lysosomal damage triggers global cellular responses, including adaptations in translation, metabolism, and transcription.
- These global responses are essential for restoring cellular homeostasis.
Conclusions:
- Lysosomal damage elicits complex cellular responses critical for survival and function.
- Global adaptations in cellular processes are key to restoring homeostasis after lysosomal injury.
- Further understanding of these responses can inform therapeutic strategies for lysosome-related diseases.
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