Related Experiment Video
Updated: May 23, 2025
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian
Fang Ren1, Lili Zhang2, Di Zhao1
1Clinical Medical School, Ningxia Medical University, Yinchuan, China.
Background:
Epidemiological investigations provide considerable evidence supporting the coexistence of upper airway ailments with lower airway disorders, but the association between common nasal diseases, such as allergic rhinitis, chronic sinusitis, nasal polyps, and chronic respiratory conditions require further exploration.
Methods:
In this study, a two-sample mendelian randomization was employed to explore the potential association between allergic rhinitis, nasal polyps, and chronic sinusitis with various chronic respiratory diseases. For the primary analysis, summary statistics related to chronic respiratory diseases were obtained from the UK Biobank of European ancestry. To externally validate the results, summary statistics related to chronic respiratory diseases were sourced from the FinnGen R10 database. The analysis incorporated various methodologies, including the inverse variance weighted method, the MR Egger method, and the weighted median method. Sensitivity analysis encompassed Cochran 's Q test, MR-Egger intercept tests, leave-one-out analyses, and the construction of funnel plots.
Results:
Allergic rhinitis was significantly associated with asthma (UKB database, OR 1.082, 95% CI 1.072-1.0924, P < 0.001; FinnGen database, OR 1.382, 95% CI 1.305-1.462, P < 0.001), COPD (UKB database, OR 1.003, 95% CI 1.001-1.006, P = 0.020; FinnGen database, OR 1.102, 95% CI 1.037-1.172, P = 0.002), ILD (UKB database, OR 1.013, 95% CI 1.010-1.017, P < 0.001; FinnGen database, OR 1.152, 95% CI 1.035-1.283, P = 0.010). Nasal polyps were potentially related to the increased risks of COPD (UKB database, OR 1.003, 95% CI 1.001-1.004, P < 0.001; FinnGen database, OR 1.092, 95% CI 1.050-1.136, P < 0.001) and bronchiectasis (UKB database, OR 1.000, 95% CI 1.000-1.001, P = 0.036; FinnGen database, OR 1.109, 95% CI 1.022-1.203, P = 0.013).
Conclusions:
This study indicates a potential relationship between allergic rhinitis and respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Additionally, the presence of nasal polyps appears to be correlated with an increased prevalence of COPD and bronchiectasis.
More Related Videos
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:29Asthma-I: Introduction
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
02:06Allergic Reactions
01:23Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...