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Updated: May 23, 2025
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Published on: November 9, 2019
Cobalt-Catalyzed Remote Site-Selective Hydroboration of Unactivated Alkenes via Chain-Walking Strategy
Zhiqiang Wang1, Mengjie Zhang1, Xue Li1
1Institute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao University, Xiamen, Fujian 361021, China.
Abstract:
An expedient synthesis of α-aminoboronic acid derivatives via cobalt-catalyzed remote site-selective hydroboration of unactivated alkenes is described herein. The strategy is characterized by its simplicity, site-selectivity, and wide substrate scope, as both terminal and internal alkenes could undergo the reaction smoothly, affording the corresponding products in good yields. According to the mechanism, Co-H is generated from Co(acac)2 in the presence of HBpin, which starts the chain-walking strategy via a series of alkene insertion and β-H elimination process.
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