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The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...

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Related Experiment Video

Updated: Jun 16, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Navigating a Giant Thyroglossal cyst: A Compelling Case Study.

Pochamallu Byra1, Bikash Bal1, Nishant Upadhyay1

  • 1Department of Surgical Oncology, Shankus Medicity, Mahesana, Gujarat India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|March 12, 2025
PubMed
Summary

Thyroglossal duct cysts (TGDC) are congenital neck masses. This case highlights successful treatment of a large TGDC using the Sistrunk procedure, with no recurrence after three years.

Keywords:
Congenital neck cystForamen caecumSistrunk procedureThyroglossal Duct CystThyroid

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Area of Science:

  • Otolaryngology
  • Surgical Pathology
  • Embryology

Background:

  • Thyroglossal duct cysts (TGDC) arise from incomplete involution of the thyroglossal duct during embryogenesis.
  • These congenital neck cysts can present as large masses, causing symptoms like dysphagia and voice changes.

Purpose of the Study:

  • To present a case of a large, long-standing thyroglossal duct cyst in an adult male.
  • To illustrate the efficacy of the Sistrunk procedure in managing complex TGDC cases.

Main Methods:

  • Clinical diagnosis based on patient history, fine-needle aspiration biopsy, and radiographic findings.
  • Surgical treatment utilizing the Sistrunk procedure, including dissection of the posterior hyoid space.

Main Results:

  • A 55-year-old male with an 11 x 8.5 cm anterior neck mass diagnosed as TGDC was successfully treated.
  • The patient experienced no recurrence or post-operative morbidity during a 3-year follow-up period.

Conclusions:

  • The Sistrunk procedure remains the standard of care for thyroglossal duct cysts.
  • This case demonstrates the long-term efficacy and safety of the Sistrunk procedure, even for large and long-standing TGDCs.