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Updated: Feb 20, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Oral Potentially Malignant Disorders and Submucous Fibrosis
Nirav P Trivedi1, Rohit N Rathod2, Nishant Upadhyay2
1Department of Head & Neck Oncology & Skull Base Surgery, Shankus Medicity, Gujarat, India.
Abstract:
This article explores the etiopathogenesis and clinical spectrum of oral potentially malignant disorders (OPMDs), with a focus on 3 high-risk entities: leukoplakia, erythroplakia, and oral submucous fibrosis (OSMF). Oral cancer, predominantly squamous cell carcinoma, is strongly influenced by lifestyle habits such as tobacco use, betel nut chewing, and alcohol consumption. Leukoplakia, the most common OPMD, presents as a persistent white patch with variable potential for dysplasia. OSMF is a chronic, progressive fibrotic condition associated with areca nut use, leading to mucosal rigidity. The article emphasizes the importance of early diagnosis, histopathological evaluation, management, and the reduction of oral cancer incidence.
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