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Updated: May 23, 2025
Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient
Olivia C Ghirardelli Smith1, Alexander K Tsai1, Minghao Zhong2
1Department of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United States.
Introduction:
We report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.
Case Discussion:
A 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass. A left testicular ultrasound identified a solid lesion suggestive of a germ cell tumor, leading to a left radical orchiectomy, which revealed a mature pure teratoma with no evidence of germ cell neoplasia in situ (GCNIS). Excision of the retroperitoneal mass confirmed the presence of mature teratomatous elements without evidence of non-teratomatous germ cell tumor elements or cytological atypia. Fluorescence in situ hybridization (FISH) showed no evidence of gain of 12p, and next-generation sequencing showed no alterations in genes known to be associated with GCT.
Conclusion:
This case illustrates that pure mature teratomas lacking chromosome 12p abnormalities, GCNIS, and other dysgenetic features, occurring in postpubertal males, cannot invariably be classified into the benign prepubertal-type teratoma category. Contrary to current paradigm, in rare cases these may represent tumors with metastatic potential.
