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Related Experiment Videos

Increased insulin binding to monocytes after acute exercise in normal man.

V R Soman, V A Koivisto, P Grantham

    The Journal of Clinical Endocrinology and Metabolism
    |July 1, 1978
    PubMed
    Summary

    Acute exercise significantly boosts insulin binding to monocytes, primarily by enhancing receptor affinity. This effect, linked to lower blood glucose, may explain exercise-induced improvements in insulin sensitivity.

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    Area of Science:

    • Endocrinology
    • Exercise Physiology
    • Metabolic Health

    Background:

    • Insulin resistance is a major health concern.
    • Exercise is known to improve insulin sensitivity.
    • The precise mechanisms of exercise-induced insulin sensitivity are not fully understood.

    Purpose of the Study:

    • To investigate the impact of acute exercise on insulin binding to monocytes.
    • To explore the relationship between exercise, insulin binding, and metabolic markers.

    Main Methods:

    • Studied 10 healthy subjects undergoing 3 hours of bicycle ergometer exercise.
    • Measured 125I-insulin binding to monocytes before, during, and after exercise.
    • Assessed plasma glucose, insulin, and ketone levels.

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    Main Results:

    • Acute exercise caused a 36% increase in monocyte insulin binding.
    • Increased binding was primarily due to enhanced insulin receptor affinity.
    • Insulin binding returned to baseline 24 hours post-exercise.
    • The rise in insulin binding correlated with a drop in plasma glucose.

    Conclusions:

    • Acute exercise enhances insulin binding to monocytes.
    • Increased insulin receptor affinity appears to be the main driver.
    • This modulation of insulin binding may contribute to improved insulin sensitivity after exercise.