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Fluorescent Silver Nanoclusters Associated with Double-Stranded Poly(dGdC) DNA.

Zakhar Reveguk1,2, Roberto Improta3, Lara Martínez-Fernández4

  • 1Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, University Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel.

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PubMed
Summary

Silver ions binding to DNA create a unique fluorescent conjugate. This novel DNA-silver material shows potential for nanodevices and nanosensors due to its conductive properties.

Keywords:
AFMDNAHRTEMfluorescencequantum mechanical calculationssilver nanoclusters

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Area of Science:

  • Biophysics
  • Materials Science
  • Nanotechnology

Background:

  • Double-stranded (ds) DNA, specifically poly(dGdC), has unique structural properties.
  • Silver ions (Ag+) are known to interact with nucleic acids, but their effects on long, repetitive ds DNA are not fully understood.

Purpose of the Study:

  • To investigate the structural and optical properties of poly(dGdC)-Ag+ conjugates.
  • To explore the potential applications of these novel DNA-silver conjugates.

Main Methods:

  • Atomic Force Microscopy (AFM) imaging
  • Circular Dichroism (CD) spectroscopy
  • Quantum Mechanical (QM) and Molecular Mechanics (MMs) calculations

Main Results:

  • Binding of Ag+ to poly(dGdC) induces a one-base shift, forming alternating CC and GG base pairs coordinated by silver ions.
  • The resulting DNA-silver conjugate exhibits strong fluorescence at 720 nm upon reduction and oxidation of silver.
  • QM and MMs calculations support the proposed structure and dynamic behavior of the conjugate.

Conclusions:

  • A novel, highly fluorescent DNA-silver conjugate with potential conductive properties has been synthesized.
  • The poly(dGdC)-Ag conjugate functions as a dynamic system with embedded silver nanoclusters.
  • These conjugates are promising candidates for applications in nanodevices and nanosensors.