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Peripheral and autonomic nerve function in glucose intolerance.

J Cederholm, J Fagius, L Wibell

    Diabete & Metabolisme
    |April 1, 1985
    PubMed
    Summary
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    Glucose intolerance may cause minor nerve function changes, but significant nerve damage is unlikely. This study compared nerve function in glucose-intolerant individuals to healthy controls.

    Area of Science:

    • Neurology
    • Endocrinology
    • Metabolic Health

    Background:

    • Glucose intolerance is a precursor to type 2 diabetes.
    • Nerve dysfunction can be an early complication of metabolic disorders.

    Purpose of the Study:

    • To investigate peripheral and autonomic nerve function in individuals with glucose intolerance.
    • To compare nerve function between glucose-intolerant subjects and healthy controls.

    Main Methods:

    • Studied 19 middle-aged subjects with glucose intolerance (WHO criteria) and 25 healthy controls.
    • Assessed clinical signs of peripheral nerve dysfunction.
    • Measured sensory thresholds for vibration, nerve conduction velocities, and autonomic nerve function.

    Main Results:

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    • No significant difference in clinically detectable peripheral nerve dysfunction between groups.
    • Minor, mostly non-significant differences in sensory thresholds, nerve conduction, and autonomic function favored controls.
    • Subtle nerve function alterations may be associated with glucose intolerance but are difficult to detect.

    Conclusions:

    • Glucose intolerance is not strongly associated with readily demonstrable peripheral or autonomic nerve dysfunction.
    • Clinically apparent polyneuropathy is unlikely to develop solely from glucose intolerance.