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EWSR1::CREM Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor
Megan M Lilley1, Patrick R Blackburn2, Larissa V Furtado2
1Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
None:
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of CTNNB1, FOXO4, TP53, NBN, MTOR, BAP1, MEN1, and CREBBP. We report a case of a testicular Leydig cell tumor with an EWSR1::CREM fusion, which to our knowledge has not been previously reported in this setting.
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