Related Experiment Video
Updated: May 22, 2025
00:04
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
10.6K
Innovation in the Design of Clinical Trials for Infectious Diseases: Focusing on Patients Over Pathogens
John H Powers1,2, Robert J O'Connell3
1Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. powersjohn@mail.nih.gov.
Pharmaceutical Medicine
|March 13, 2025
Summary
Current infectious disease research, focusing on in vitro drug activity, often fails to improve patient outcomes. A shift towards patient-centered research is crucial for better clinical evidence and effective treatments.
Area of Science:
- Infectious disease research
- Clinical microbiology
- Translational medicine
Background:
- In vitro antimicrobial susceptibility testing does not fully predict clinical outcomes.
- Suboptimal patient outcomes persist despite in vitro drug susceptibility.
- Current research paradigms overlook the immune system's role and real-world clinical questions.
Purpose of the Study:
- To advocate for a paradigm shift in infectious disease research.
- To emphasize the need for research focused on improving patient outcomes.
- To highlight the limitations of current in vitro-centric approaches.
Main Methods:
- Critically analyze current infectious disease research methodologies.
- Identify the disconnect between laboratory findings and clinical practice.
- Propose changes in research questions, patient selection, interventions, and outcome evaluation.
Main Results:
- Current research often fails to address critical clinical questions.
- Focusing solely on in vitro susceptibility is insufficient for improving patient care.
- A shift in research focus is necessary to generate clinically relevant evidence.
Conclusions:
- Infectious disease research must prioritize patient outcomes over in vitro activity.
- Reorienting research will lead to better evidence for patient care.
- This shift will better justify the development and payment of new interventions.
Related Concept Videos
01:16Clinical Trials
6.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.6K
01:20Infection
7.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.0K
01:27Nursing Clinical Information System
744
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
744
01:22Healthcare Associated Infections II: Preventive Measures
2.3K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.3K
01:18Steps in Outbreak Investigation
102
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
102
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
110
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
110