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Serum Tumor Markers for Muscle-Invasive Bladder Cancer in Clinical Practice: A Narrative Review
Chirag Doshi1, Mazyar Zahir1, Anosh Dadabhoy1
1Catherine and Joseph Aresty Department of Urology, University of Southern California, 1441 Eastlake Ave. NOR 7416, Los Angeles, CA 90089-9178, USA.
Cancers
|March 13, 2025
Summary
Serum tumor markers (STMs) are valuable for early cancer detection and monitoring treatment response. This review explores their broader applications in muscle-invasive bladder cancer (MIBC), supported by clinical insights.
Area of Science:
- Oncology
- Biochemistry
Background:
- Serum tumor markers (STMs) are increasingly utilized for cancer detection and surveillance.
- STMs offer a cost-effective, minimally invasive approach for cancer management.
- Recent evidence highlights the prognostic value of STMs in bladder cancer (BC).
Purpose of the Study:
- To review the multifaceted applications of STMs in muscle-invasive bladder cancer (MIBC).
- To explore the utility of STMs beyond prognostication in MIBC.
- To present clinical experiences demonstrating the feasibility of STMs in MIBC.
Main Methods:
- Comprehensive literature review on STM applications in MIBC.
- Analysis of existing evidence regarding STM reliability and utility.
- Inclusion of institutional clinical case examples.
Main Results:
- STMs show promise in early detection and monitoring of bladder cancer.
- Applications extend beyond prognostication, aiding in treatment response assessment and recurrence detection.
- Clinical data supports the practical implementation of STMs in MIBC management.
Conclusions:
- STMs are versatile tools in the management of muscle-invasive bladder cancer.
- Their accessibility and minimally invasive nature make them valuable for comprehensive patient care.
- Further integration of STMs into clinical practice for MIBC is warranted.
