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Published on: February 17, 2017
Novel One-Step Total Synthesis of trans-Dehydroosthol and Citrubuntin
Zhiwen Liu1, Baoyue Ge1, Xushun Gong1
1College of Pharmacy, Dali University, Dali 671000, China.
Abstract:
Efficient and simple syntheses of trans-dehydroosthol and citrubuntin were achieved in a single step by implementing a protecting-group-free, redox-neutral strategy that utilized readily available starting materials. In this approach, a practical one-pot (domino) Heck/dehydration reaction was carried out utilizing less reactive bromocoumarin, resulting in excellent stereoselectivity and atomic economy. Through the implementation of this new, efficient, and scalable synthesis method, the formal synthesis of a series of novel meroterpenoid natural products was successfully achieved.
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