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Related Concept Videos

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
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Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

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Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Advanced Materials for Oral Application (Volume 2).

Laura-Cristina Rusu1, Lavinia Cosmina Ardelean2

  • 1University Clinic of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

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This summary is machine-generated.

This editorial highlights advanced materials for oral applications, focusing on innovations in dental and oral health. Discover cutting-edge research shaping the future of oral care and biomaterials.

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Nanotechnology in Oral Health

Background:

  • This editorial introduces the second volume of the Special Issue on Advanced Materials for Oral Application.
  • It highlights recent advancements and their impact on dental and oral health.
  • The focus is on materials designed for direct application within the oral cavity.

Discussion:

  • Explores the integration of novel materials in restorative dentistry.
  • Discusses the development of smart materials for drug delivery and diagnostics in oral care.
  • Addresses challenges and opportunities in translating laboratory innovations to clinical practice.

Key Insights:

  • Showcases innovative biomaterials with enhanced biocompatibility and functionality for oral use.
  • Highlights the role of nanotechnology in improving dental material performance.
  • Emphasizes the interdisciplinary nature of advanced materials research for oral applications.

Outlook:

  • Predicts future trends in personalized oral healthcare solutions.
  • Suggests potential for regenerative dentistry applications using advanced materials.
  • Encourages further research and collaboration in the field of oral biomaterials.