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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Updated: May 22, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause.

Amy L Barnett1, Michael J Wenger1, Pamela Miles2

  • 1Psychology and Cellular and Behavioral Neurobiology, The University of Oklahoma, Norman, OK 73019, USA.

Nutrients
|March 13, 2025
PubMed
Summary

Higher iron status correlates with improved cognitive function in women nearing menopause. This suggests that managing iron levels may help reduce menopausal "brain fog."

Keywords:
agingattentionironmemoryperimenopause

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Area of Science:

  • Neuroscience
  • Iron Metabolism
  • Cognitive Function

Background:

  • The link between blood iron, brain iron, and cognition during menopause is unclear.
  • Iron accumulation in the brain over time may contribute to neurodegenerative diseases.
  • Understanding these relationships is crucial as women cease monthly blood loss.

Purpose of the Study:

  • To investigate the associations between iron status, cognitive performance, and brain iron levels in women transitioning through menopause.
  • To explore the potential impact of iron status on cognitive function and brain dynamics.

Main Methods:

  • Recruited non-anemic women with low or normal iron levels.
  • Collected blood samples to assess iron status.
  • Utilized MRI scans to estimate brain iron levels.
  • Administered cognitive tasks with concurrent electroencephalography (EEG).

Main Results:

  • Cognitive performance and brain dynamics showed a positive association with iron levels.
  • Measures related to oxygen transport were positively linked to iron status.
  • No correlation was found between blood iron measures and brain iron levels.

Conclusions:

  • Elevated iron status was linked to better cognitive performance in women who were not iron deficient or anemic.
  • Higher systemic iron levels did not correlate with increased brain iron.
  • Optimizing iron status during menopause may alleviate "brain fog."