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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

419
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Correction: Pramesthi et al. Evaluating the Impact of Indonesia's National School Feeding Program (ProGAS) on Children's Nutrition and Learning Environment: A Mixed-Methods Approach. <i>Nutrients</i> 2025, <i>17</i>, 3575.

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Updated: May 22, 2025

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
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Host Transcriptome and Microbial Variation in Relation to Visceral Hyperalgesia.

Christopher J Costa1, Stephanie Prescott2, Nicolaas H Fourie3

  • 1Department of Medicine, UConn Health, 263 Farmington Ave, Farmington, CT 06030, USA.

Nutrients
|March 13, 2025
PubMed
Summary
This summary is machine-generated.

The oral microbiome

Keywords:
abdominal painabdominal pain [D015746]gene expressionhuman microbiome [D064307]microbiomeoralvisceral hyperalgesiavisceral pain [D064307]

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Chronic visceral hypersensitivity involves an amplified pain response.
  • Microbiota significantly influence host biology and visceral hypersensitivity development.

Purpose of the Study:

  • To investigate the link between circulating mRNA transcriptome, induced visceral pain (IVP) intensity, and oral microbiome variations.
  • To explore associations in individuals with and without baseline visceral hypersensitivity.

Main Methods:

  • Correlated transcriptomic profiles and microbial abundance with IVP intensity.
  • Examined host mRNA and microbes linked to IVP, connecting microbiome variations to host RNA biology.

Main Results:

  • 259 operational taxonomic units (OTUs) associated with IVP, correlating with differential expression of 471 genes in inflammation and neural pathways.
  • Bacterial families Lachnospiraceae, Prevotellaceae, and Veillonellaceae showed strong associations.
  • Reduced oral microbial diversity characterized participants with visceral hypersensitivity.

Conclusions:

  • The oral microbiome may influence systemic immunity, inflammation, and neural pathways.
  • Interactions between visceral hypersensitivity, gene expression, and microbiota offer a framework for future research.
  • Highlights the intricate relationship between host and microbiome in visceral pain.