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Calcium phosphate-based anti-infective bone cements: recent trends and future perspectives
Xiang Liu1, Chaoli Wang2, Han Wang1
1Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, China.
Frontiers in Pharmacology
|March 13, 2025
Summary
Calcium phosphate cements (CPCs) offer a promising local treatment for bone infections, delivering antibacterial agents effectively. Combining CPCs with calcium sulfate creates multifunctional bone cements that fight infection and promote bone healing.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Orthopedic Surgery
Background:
- Bone infections are difficult to treat with systemic antibiotics due to poor local drug delivery and resistance.
- Bone cement acts as a local drug delivery matrix, showing clinical efficacy against bone infections.
- Calcium phosphate cements (CPCs) are injectable, biocompatible, and degradable, making them suitable for bone infection management.
Purpose of the Study:
- To review antibacterial strategies utilizing calcium phosphate cement for bone infection prevention and treatment.
- To discuss the application of calcium phosphate-calcium sulfate composites in multifunctional bone cements.
Main Methods:
- Review of studies integrating various antimicrobial agents (antibiotics, peptides, ions, graphene, iodine) into CPC matrices.
- Investigation of CPC applications in bone defect filling and implant coatings.
- Analysis of calcium phosphate-calcium sulfate composites for enhanced bone infection treatment.
Main Results:
- CPCs provide an osteoconductive and osteoinductive porous structure ideal for housing antibacterial agents.
- Diverse antimicrobial agents successfully incorporated into CPCs demonstrate potential for treating bone infections.
- Calcium phosphate-calcium sulfate composites show promise for multifunctional bone cement applications, addressing infection and bone regeneration.
Conclusions:
- Calcium phosphate cements represent a versatile platform for developing effective local antibacterial therapies for bone infections.
- Multifunctional calcium phosphate-calcium sulfate composites offer a dual approach to combat infection and enhance bone healing in challenging cases.
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