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Coupling of chromatography with surface-enhanced Raman spectroscopy: trends and prospects
Ekaterina V Dmitrieva1,2, Olesya O Kapitanova2, Shixian Lv3
1Faculty of Material Sciences, Shenzhen MSU-BIT University, Shenzhen, China.
Frontiers in Chemistry
|March 13, 2025
Summary
Surface-enhanced Raman spectroscopy (SERS) offers sensitive analysis, but complex samples pose challenges. Coupling SERS with chromatography enhances analyte quantification and identification in intricate mixtures.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Chromatography
Background:
- Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical technique providing structural information for compound identification.
- Complex samples often present challenges for SERS due to matrix component interference, affecting analyte quantification.
- Existing methods like extraction techniques aim to mitigate these interferences.
Purpose of the Study:
- To review recent advancements in combining chromatography with SERS.
- To highlight the synergistic benefits of integrating these two powerful analytical techniques.
- To demonstrate the potential for simultaneous quantification of multiple analytes in complex matrices.
Main Methods:
- Literature review of recent research combining chromatography and SERS.
- Analysis of strategies for overcoming matrix effects in SERS analysis.
- Evaluation of the performance of hyphenated chromatography-SERS systems.
Main Results:
- The combination of chromatography and SERS offers high separation efficiency and sensitive detection.
- This hyphenated technique enables simultaneous quantification of multiple analytes.
- Recent achievements demonstrate improved performance in complex sample analysis.
Conclusions:
- Coupling chromatography with SERS is a promising approach for analyzing complex samples.
- This integrated technique overcomes the limitations of individual methods, enhancing quantification and identification.
- The review highlights the latest successful applications and future potential of this powerful analytical combination.
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