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Hemophilia is associated with accelerated biological aging
Marina Trappl1, Rafaela Vostatek1, Manuel Salzmann2
1Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna.
Haematologica
|March 13, 2025
Summary
Persons with hemophilia (PwH) may experience accelerated biological aging. This study found shorter telomere length in PwH compared to controls, suggesting a link between hemophilia and aging biomarkers.
Area of Science:
- Hematology
- Genetics
- Aging Research
Background:
- Hemophilia (hemophilia A or B) is a rare X-linked bleeding disorder due to F8 or F9 gene mutations, impacting Factor VIII or IX levels.
- Joint bleeding and age-related conditions are common in persons with hemophilia (PwH), affecting quality of life.
- The chronic nature of hemophilia suggests a potential association with accelerated biological aging.
Purpose of the Study:
- To investigate biological aging biomarkers, specifically telomere length and mitochondrial DNA (mtDNA) copy number, in persons with hemophilia (PwH).
- To explore the association between hemophilia and accelerated biological aging.
- To examine the relationship between telomere length, mtDNA copy number, and hemophilia severity.
Main Methods:
- Quantitative PCR assay used to measure telomere length and mtDNA copy number.
- Study included 99 individuals with hemophilia and 61 age- and sex-matched healthy controls.
- Ordinary-least-squares linear regression models analyzed associations, including interactions with chronological age.
Main Results:
- Telomere length was significantly shorter in PwH (6.09 [4.79-7.68] kb) compared to healthy controls (10.07 [7.93-12.66] kb) (p < [specific p-value not provided in abstract]).
- Mitochondrial DNA (mtDNA) copy number analysis results were not detailed in the provided abstract.
- Further analysis explored the association of these biomarkers with hemophilia severity and chronological age.
Conclusions:
- Hemophilia may be associated with accelerated biological aging, indicated by shorter telomere length.
- Telomere length and mtDNA copy number warrant further investigation as potential biomarkers in hemophilia management.
- Understanding the aging process in PwH is crucial for improving long-term health outcomes and quality of life.
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