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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
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In situ self-assembled peptide nanoparticles improve the anti-hepatic fibrosis effect
Wenbin Liu1, Beibei Wang1, Mengxing Wei2,3
1Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China. zijuan@ahu.edu.cn.
Journal of Materials Chemistry. B
|March 13, 2025
Abstract:
Antagonistic peptide Leu-Ser-Lys-Leu (LSKL) is capable of blocking the transforming growth factor-β1 (TGF-β1) signaling pathway and exhibits anti-fibrotic effects. Herein, we constructed LSKL nanoparticles (NPs) in situ based on an alkaline phosphatase (ALP)-instructed self-assembly strategy for improving its specific therapeutic effect against liver fibrosis.

