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Updated: May 22, 2025
Technique and Considerations in the Use of 4x1 Ring High-definition Transcranial Direct Current Stimulation HD-tDCS
Published on: July 14, 2013
Design and optimization of a high-definition transcranial electrical stimulation device with envelope wave
Renling Zou1, Linpeng Jin1, Yuhao Liu1
1University of Shanghai for Science and Technology, Shanghai, China.
Objectives:
Transcranial electrical stimulation (tES) has been widely used in neuroscience research, and the spatial focusing and penetration of the process are currently the main constraints on the effectiveness of treatment.
Methods:
A high-definition electrical stimulation (HD-tES) device with envelope waves was designed. The device utilized a 4 × 1 electrode structure and was designed with an impedance adjustment circuit to evenly distribute the current among the four return channels. The output performance and safety of the device were verified in in vitro experiments. The spatial focusing of the 4 × 1 electrode structure and the high penetration advantage of envelope waves are explored through simulations. Finally, experiments were performed on 10 healthy adults.
Results:
The 4 × 1 electrode structure has the best spatial focusing effect. Current frequencies above 1 kHz may have higher tissue penetration. In addition, the safety of envelope wave stimulation has been verified in human trials, and no adverse reactions occurred during stimulation.
Conclusions:
The low and medium frequency (<10 kHz) envelope wave HD-tES device is expected to have a positive impact in the field of medicine and neuroscience.
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