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Updated: May 22, 2025

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Selective C(sp2)-P Cross-Coupling of Alkenylsulfonium Salts with P(O)H Compounds: Divergent Synthesis of
Jing Xiao1, Dequan Xie1, Lude Wang1
1Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China.
Abstract:
Herein, we report a both regioselective and stereoselective method for the formation of C(sp2)-P bonds using alkenylsulfonium salts and >P(O)-H compounds. By employing a palladium catalyst or K2CO3, a variety of (E)-alkenylphosphorus compounds and terminal alkenylphosphorus compounds were successfully synthesized with high selectivity. Notably, trisubstituted (Z)-alkenylphosphorus compounds were synthesized for the first time under metal-free conditions. This protocol has a wide substrate scope and good functional group compatibility, providing a direct and highly selective approach for the preparation of various alkenylphosphorus compounds.
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