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Related Experiment Videos

Particulate oral NMR contrast agents.

V M Runge, M A Foster, J A Clanton

    International Journal of Nuclear Medicine and Biology
    |January 1, 1985
    PubMed
    Summary

    Insoluble paramagnetic compounds enhance gastrointestinal visualization in magnetic resonance imaging (NMR). Gadolinium oxalate effectively opacified the upper GI tract orally and the colon rectally in rabbit studies.

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    Area of Science:

    • Biomedical imaging
    • Magnetic Resonance Imaging (NMR)

    Background:

    • Insoluble paramagnetic compounds can visualize the gastrointestinal system using NMR.
    • Particulate contrast agents shorten T1 and T2 relaxation times.

    Purpose of the Study:

    • To evaluate gadolinium oxalate as a prototype particulate contrast agent for NMR imaging of the gastrointestinal tract.
    • To assess the in vitro and in vivo efficacy of gadolinium oxalate.

    Main Methods:

    • In vitro and in vivo evaluation of gadolinium oxalate using NMR imaging.
    • Quantification of T1 and T2 effects in vitro using NMR spectroscopy.
    • Administration of gadolinium oxalate orally and rectally in rabbits.

    Main Results:

    • Gadolinium oxalate demonstrated opacification of the upper gastrointestinal tract after oral administration.

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  • Visualization of the colon was achieved following rectal administration.
  • In vitro studies confirmed the compound's effect on T1 and T2 relaxation times.

    • Conclusions:

    • Gadolinium oxalate is an effective particulate contrast agent for NMR imaging of the gastrointestinal tract.
    • The route of administration influences the visualization of different gastrointestinal segments.
    • Particulate paramagnetic agents show promise for GI NMR imaging.